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Best Marijuana Strains for Migraines

Updated: Jan 30


Now that we've established that cannabis, be it CBD or THC, can definitely help with migraines, how do you choose a strain. It's not easy when you walk in the dispensary and are given a vast menu full of intimidating names you likely won't know—even if this isn't your first rodeo.

We asked Ann Marie Wong M.D., one of Florida's premier Marijuana Doctors if it matters. "All marijuana has the potential to help migraines via the endocannabinoid receptors, but some strains seem to work better than others," she says. "I usually recommend Blue Dream, OG Kush, or Trainwreck. These are easy to find and work well for my patients. But it is very individual," adds Dr. Wong.

Indeed. Just as different people react differently to various migraine rescue medications, different strains work differently on everyone, so some experimentation is needed. Personally I have had a lot of success with Trainwreck. It literally takes a wrecking ball to my migraine in 2-3 minutes.

Interestingly, the strains that are recommended for migraines are of the sativa-dominant variety. This is the kind that usually gives you a little extra get-up-and-go, although if you have a migraine, they probably won't have that effect on you. That said, if you are hoping to lay in bed and sleep off your migraine, strains with higher indica proportions will be your best bet.


  • Harlequin. (High CBD ratio gives this strain minimal psychoactive effects)

  • AC/DC (High CBD ration gives minimal psychoactive effects. This strain is highly analgesic and anti-inflammatory)

  • Sour Diesel (Sativa dominant 90-10 - lineage: Chemdawg x Super Skunk)

  • Jack Herer (Sativa leaning 55-45 hybrid, clear headed, focused)

  • White Widow (Sativa leaning 60-40 hybrid: offspring: White Rhino + Moby Dick)

  • Blue Dream (Sativa-dominant 60-40 hybrid- lineage Super Silver Haze x Blueberry Indica)

  • Trainwreck (Sativa-dominant 90-10 hybrid: offspring:Pineapple Express + Kandy Kush)


  • OG Kush (Indica-leaning 55-45 hybrid)

  • Skywalker (50-50 hybrid strain: Dutch Passion x OG Kush)

If you can't find one of the strains listed above at your dispensary, look for others that have a relation to one of these either via parentage or offspring.


The body has an endocannabinoid system that creates its own cannabinoids and also uses exogenous ones. According to Dr. Wong, using cannabis "Helps to upregulate the endocannabinoid system, helping the body make more of it's own cannabinoids. This means some individuals will use it for a while and then be able to stop and still see benefits. This is good news and runs counter to the way other medication works.


If you are a migraine sufferer, discuss marijuana for migraines with your doctors. Even if you live in a state with legal recreational marijuana, and there are no qualifications for purchase, it is important to check for any contraindications with your doctor. Those with cardiovascular conditions or a history of or family history of mental illness or addiction should not use marijuana. If you are already cleared for marijuana use by your doctor and are shopping for cannabis, remember to check TCH levels. Starting with the lowest effective percentages and the lowest dosages is advised to mitigate undesirable side effects.



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